Dr. Ram Pratap Singh
PhD (CARI and M. J. P. Rohilkhand University, Bareilly)
Associate Professor
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Areas of Expertise/Research interest:

Dr. Ram Pratap Singh is Associate Professor of Life Science at the Central University of South Bihar. Dr. Singh handles courses related to Animal Science especially Animal Physiology, Developmental Biology and Endocrinology to undergraduate and post-graduate levels. Such courses offer Dr. Singh the opportunity to guide students on their journey to understanding the biology of life, a pursuit he is very passionate about.

Research interests: The primary focus of Dr. Singh’s research is to understand the Physiology and genetics of birds and other animals. His major research interests include the reproductive biology of birds, especially rare and endangered species, mitigating infertility, developing assisted reproductive technologies, gamete cryopreservation, avian forensics, genome resource banking, avian genomics, etc. Dr. Singh and his team has developed semen preservation and assisted reproductive technologies for a variety of common and rare species of birds and other animals. Currently, Dr. Singh is involved in developing species-specific DNA and feather signatures for birds to generate a comprehensive database for Indian birds which could be a valuable reference for forensic analysis and various other fields including phylogenetics. Dr. Singh’s research on plumology soon would lead to India’s first systematic ‘Feather Atlas’.
Professional contributions / achievements: So far, his most important contribution is the establishment of ‘National Avian Forensic Laboratory (NAFL)’ at Salim Ali Centre for Ornithology and Natural History, Coimbatore. Under Dr. Singh’s leadership, the NAFL also have started a Genome Resource Bank (GRB) for preserving biomaterials of birds for research and conservation purposes. It has already acquired biomaterials from 20% of the Indian birds and has helped resolve many intricate issues such as the one relating to the Mig-21 crash in Bikaner in 2019 due to bird hit. Dr. Singh has contributed significantly to developing MoEFCC’s Visionary Perspective Plan for Avian Conservation in India for 2020-2030. Dr. Singh has served as member of the ‘ad-hoc Animal Committee’ of the National Board for Wildlife, MoEFCC, Govt. of India. Dr. Singh also served as a member of various other committees of MoEFCC, Govt. of India, on ‘Alteration of Schedules of Wildlife (Protection Act), 1972’, ‘Farming and Trade in Japanese quail’ and ‘Research on the Wild Relatives of Domestic Animal Species’.
Dr. Singh has obtained over 1000 Lakh Rupees funding for research and other academic activities from various national and international agencies such as the Indian National Science Academy (INSA), Department of Science and Technology (DST), Department of Biotechnology (DBT), Ministry of Environment, Forest and Climate Change (MoEFCC), Indo-U.S. Science and Technology Forum (IUSSTF), United States-India Education Foundation (USIEF), Fulbright Commission – USA, Smithsonian Institution – USA, University of Maryland – USA, The Royal Society of Edinburg – Scotland, Government of Australia, Poultry Foundation – The Netherlands, The Society for the Study of Reproduction – USA, World’s Poultry Science Association – Brazil, World’s Poultry Science Association – Australia,  and British Poultry Science – UK.
Academic awards / fellowships: Dr. Singh has received several national and international fellowships/awards. International awards/fellowships to his credit include Fulbright-Nehru Fellowship, Indo-US Research Fellowship, Endeavour Research Fellowship, Young Scientist Award (24th World’s Poultry Congress, Brazil), Young Scientist Award (17th International Congress on Animal Reproduction, Canada), Young Scientist Award (23rd World’s Poultry Science Congress, Australia). National awards/fellowships include the Indian National Science Academy (INSA) Medal for Young Scientist – 2014, INSA Bilateral Exchange Fellowship – 2019, J. N. Pandey Memorial Award (Society of Animal Physiologists of India, Kolkata), DBT – Research Associateship Award (DBT, Govt. of India), and Best Oral Presentation Award (Indian Poultry Science Association).

Dr. Sanjay Kumar
PhD - Jawaharlal Nehru University, New Delhi
Assistant Professor
Ramalingaswami fellow, Department of biotechnology, Govt. of India.
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Areas of Expertise/Research interest:

Study of molecular mechanism of free heme toxicity, antioxidant defense system, and screening of new antimalarial active molecules using in vitro (Plasmodium falciparum, N54) in vivo (Plasmodium yoelii) models. TRPC Channels role in metabolic syndrome and neurite outgrowth using pig and hippocampal neuron as models. Signaling cascade are involved in restenosis, smooth muscle cells proliferation, migration, and neointima formation using rat carotid artery model. Investigation of new and novel target in blood cancer using transgenic & nude mice through utilization of advance molecular, imaging, CRISPER-Cas9, and RNAi tools. After completion of PhD from Jawaharlal Nehru University, I was moved to Indiana university [IUPUI], University of Tennessee, and Jackson state University for completion of postdoctoral research experiences in USA several years upto August, 2019. I was remained as an assistant professor at university department of botany and coordinator at university department of biotechnology, LNMU, Darbhanga till 15th June, 2019. I have funded Ramalingaswami fellowship research project in blood cancer for next five years. I am serving as reviewer of circulation, circulation research, and life sciences journals.

Publication:

  • Sanjay kumar, Paul B. Tchounwou. Arsenic Trioxide Reduces the Expression of E2F1, Cyclin E, and Phosphorylation of PI3K Signaling Molecules in Acute Leukemia Cells. Revised manuscript in press. Scientific Reports (2020).
  • Sanjay kumar, Paul B. Tchounwou. Trisenox disrupts MDM2-DAXX-HAUSP complex and induces apoptosis in a mice model of acute promyelocyte leukemia.  J. Cancer, 11 (2020): 4373-4383.  doi:10.7150/jca.39996.
  • Andrea Brown, Sanjay Kumar, Paul B Tchounwou. Cisplatin-Based Chemotherapy of Human Cancers. J Cancer Sci Ther11(2019):097-103. doi: 10.4172/1948-5956.1000592.
  • Paul B. Tchounwou, Clement G. Yedjou,  Udensi K. Udensi, Maricica Pacurari, Jacqueline J. Stevens, Anita K. Patlolla, Felicite Noubissi, and Sanjay Kumar.  State of the science review of the health effects of inorganic arsenic: perspectives for future research. Environmental Toxicology 34 (2019): 188-202.
  • Sanjay kumar, Andrea Brown, Paul B. Tchounwou. Trisenox disrupts MDM2-DAXX-HAUSP complex and activates p53, cell cycle regulation and apoptosis in acute leukemia cells. Oncotarget 9 (2018): 33138-33148.
  •  Sanjay kumar, Ibrahim O. Farah, Paul B. Tchounwou. Trisenox induces cytotoxicity through phosphorylation of mitogenactivated protein kinase molecules in acute leukemia cells. J Biochem Mol Toxicol. 32 (2018) :e22207.
  • Sanjay kumar, Paul B. Tchounwou.  Molecular mechanism of cisplatin cytotoxicity in acute leukemia cells. Oncotarget  6 (2015): 40734-40746.
  •  Sanjay kumar, Clement J. Yedju and Paul B. Tchounwou. Arsenic trioxide induces oxidative stress, DNA damage, and mitochondrial pathway of apoptosis in human leukemia (HL-60) cells. J Exp Clin Cancer Res. 33(2014): 42.
  •  Venkatesh Kundumani-Sridharan, Nikhlesh K. Singh, Sanjay Kumar and Gadiparthi N.Rao., Nuclear factor of activated T cells c1 mediates p21-activated kinase 1 activation in the modulation of chemokine-induced human aortic smooth muscle cell F-actin stress fiber formation, migration and proliferation and injury-induced vascular wall remodeling. J.  Biol. Chem. 288(2013): 22150-22162.
  •  Nikhlesh K. Singh, Venkatesh Kundumani-Sridharan, Sanjay Kumar, Shailendra K. Verma, Sivareddy Kotla, Hideyuki Mukai, Heckle M.R  and Gadiparthi N.Rao.PKN1 is a novel substrate for NFATc1-mediated cyclin D1-CDK6 activity and modulates vascular smooth muscle cell division and migration leading to inward blood vessel wall remodeling. J. Biol. Chem. 287(2012):36291-36304.
  •  Sanjay Kumar, Saikat Chakraverty, Cindy Balbosa, Tatiana Brustovetsky, NickolayBrustovetsky and Alexander G. Obukhov. Mechanisms controlling neurite outgrowth in Rat pheochromocytoma cell line: The role of TRPC channels. J. Cell. Physiol. 227 (2012):1408-1419.
  •  Saikat Chakraverty, Zachary C.Berwick, Paula J.Bartlett, Sanjay Kumar, Andrew P.                      Thomas, Michael Sturek, Jonathan D. Tune, and Alexander G. Obukhov. Bromoenol Lactone (BEL) inhibits Cav1.2, and TRPC channels. J. Pharmacol. Exp. Ther.339 (2011):329-340.
  • Zachary P. Neeb, Jason M. Edwards, Mouhamad A. Alloosh, Xin Long, Ian N. Bratz,Cassandra R. Peller, James P. Byrd, Sanjay Kumar, Alexander G. Obukhov, Michael Sturek.   Exercise training decreases store-operated Ca2+ entry associated with metabolic syndrome and coronary atherosclerosis. Cardiovasc. Res. 85(2010) 631-640.
  •  Guoqing Hu, Elena A. Oboukhova, Sanjay Kumar, Michael Sturek, Alexander G.  Obukhov. Canonical Transient Receptor Potential Channels Expression is Elevated in a Porcine Model of Metabolic Syndrome. Mol. Endocrinol. 23(2009), 689-699.
  • Sanjay Kumar, Mithu Guha, Vinay Choubey, Pallab Maity, Kumkum Srivastava, Sunil K Puri and Uday Bandyopadhyay. Bilirubin inhibits Plasmodium falciparum        growth through the generation of reactive oxygen species. Free Rad. Biol. Med. 44 (2008), 602-613.
  •  Sanjay Kumar, Sajal Kumar Das, Sumanta Dey,  Pallab Maity, Mithu Guha, Vinay Choubey, Gautam Panda and Uday Bandyopadhyay. Antiplasmodial Activity of [(Aryl) arylsulfanylmethyl]pyridine.Antimicrob. Agents Chemother. 52 (2008),      705-715.
  • Sanjay Kumar, Mithu Guha, Vinay Choubey, Pallab Maity, Uday Bandyopadhyay “Antimalarial drugs inhibiting hemozoin (β hematin) formation: A mechanistic update. Life Sci. 80 (2007), 813-828.
  • Sanjay Kumar, Uday Bandyopadhyay “Free heme toxicity and its detoxification systems in   human. Toxicol.Letts. 157 (2005), 175-188.
  •   Mithu Guha, Sanjay Kumar,Vinay Choubey, Pallab Maity, Uday Bandyopadhyay.  “Apoptosis in the liver during malaria: Role of oxidative stress and implication of the mitochondrial pathway.” FASEB J. 20 (2006), E439-E449.
  • Vinay Choubey, Mithu Guha, Pallab Maity, Sanjay Kumar, Resmi Raghunandan, Prakas R. Maulik, Umesh C. Halder, Uday Bandyopadhyay “Molecular characterization and localization of Plasmodium falciparum  choline kinase.” Biochim Biophys Acta. 1760 (2006), 1027-1038.
  • Mithu Guha, Vinay Choubey, Pallab Maity, Sanjay Kumar, Kumkum Shrivastava, Sunil K. Puri and Uday Bandyopadhyay. Overexpression, purification and localization of apoptosis related protein from Plasmodium falciparum. Protein Expr.Purif. 52 (2007), 363-372.
  • Vinay Choubey, Pallab Maity, Mithu Guha, Sanjay Kumar, Kumkum Shrivastava, Sunil Kumar Puri and Uday Bandyopadhyay. Inhibition of Plasmodium falciparum choline kinase by hexadecyltrimethylammonium bromide: A possible antimalarial mechanism of hexadecyltrimethylammonium bromide. Antimicrob. Agents Chemother. 51 (2007), 696-706.

Book Chapter

  • Tchounwou PB, Udensi KU, Isokpehi RD, Yedjou CG, Kumar S. 2015. Arsenic and cancer. Chapter 23 in Handbook of Arsenic Toxicology. Flora SJS (Ed). Elsevier Inc. London. pp 533-555.

<<More >>

Dr. Manoj Panchal 
PhD - Hormone Biochemistry from Delhi University
Assistant Professor
Email : This email address is being protected from spambots. You need JavaScript enabled to view it.


He completed his master degree in Biosciences and qualified CSIR NET-JRF. After completion of PhD from Delhi University he received DBT-PDF. He further worked as research associate at ICGEB, New Delhi.

Areas of Expertise/Research interest :

One of my areas of interest is to trace the pathway of the protein concentration in secretory vesicles by studying various proteins which interact with the secretory proteins. Pituitary and its protein hormones are taken as model system for secretory proteins.

For a normal functioning and survival of the malaria parasite, Plasmodium falciparum, transporting between nucleus and cytoplasm is compulsory. Importins and exportins are responsible for such transports. Study of the transport in Plasmodium falciparum is another area of interest. 
Presently he is PI and Co-PI in two different projects.

He has published his work in various international journals ; Biochimica et Biophysica Acta (2015), Cell Death Dis. (2014), Preparative Biochemistry and Biotechnology (2010), Journal of Immunoassay & Immunochemistry, Clinica Chimica Acta, (2007), Behavioral Brain Reseach (2004).

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