Highlights

Department of Bioinformatics

Computational approach to identify underlying mechanism of herbal drugs

In the area of molecular drug design, Professor Rathore in collaboration with scientists at University of Hyderabad has developed a novel method to elucidate underlying mechanism of action of Ayurvedic and herbal drugs. Mankind has consumed traditional Ayurvedic, Unani and various herbal drugs from the time immemorial. The scientific rationale of these drugs has eluded us until yet. The research published in a Wiley Journal of Chemical Biology and Drug Design describe the method that not only identifies the active molecules, but also the underlying mechanism of their action. This opens up a whole range of innumerable possibilities to use traditional natural herbs as starting point to design novel drugs with less or no side effects. This technology has potential to cut down cost and time involved in making a new drug

References

• Potshangbam AM, Polavarapu R, Rathore RS*, Naresh D, Prabhu NP, Potshangbam N, et al. Med PS erver: A database for identification of therapeutic targets and novel leads pertaining to natural products. Chemical Biology & Drug Design (Wiley). 2019;93(4):438–46. https://doi.org/10.1111/cbdd.13430
• The IKK/NF-κB signaling pathway requires Morgana to drive breast cancer metastasis Federica Fusella, Laura Seclì, Elena Busso, Anna Krepelova, Enrico Moiso, Stefania Rocca, Laura Conti, Laura Annaratone, Cristina Rubinetto, Maurizia Mello-Grand, Vijay Singh, Giovanna Chiorino, Lorenzo Silengo, Fiorella Altruda, Emilia Turco, Alessandro Morotti, Salvatore Oliviero, Isabella Castellano, Federica Cavallo, Paolo Provero, Guido Tarone & Mara Brancaccio, Nature Communications volume 8, Article number: 1636 (2017)

Department of Geology