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Associate Professor

Qualification : M.Tech, PhD
Specialization : Biological Databases, Computer aided drug-designing, Computational Biology, Immunoinformatics, Next generation sequencing data Analysis, Cancer informatics

Experience : 15 Years. Dr. Ajay Kumar Singh is working as Associate Professor in the Department of Bioinformatics of Central University of South Bihar, Gaya. He has earned his doctorate in Bioinformatics from Dr. APJ Abdul Kalam Technical University, Lucknow (formerly as UPTU, Lucknow), M.Tech.-IT (Specialization in Bioinformatics from I.I.I.T, Allahabad and M.Sc. Biotechnology from C.S.J.M. University, Kanpur. He started his research carrier during his Ph.D. on topic “Design and development of antitumor and anti-angiogenic drugs specially enzyme inhibitors for oral and cervical cancers”. 

Dr. Ajay Kumar Singh working as Associate Professor in department of Bioinformatics of Central University of South Bihar, Gaya. He has earned his doctorate in Bioinformatics from Dr. APJ Abdul Kalam Technical University, Lucknow (formerly as UPTU, Lucknow), M.Tech.-IT (Specialization in Bioinformatics from I.I.I.T, Allahabad and M.Sc. Biotechnology from C.S.J.M. University, Kanpur. He started his research carrier during his Ph.D on topic “Design and development of antitumor and anti-angiogenic drugs specially enzyme inhibitors for oral and cervical cancers”. He and his team (Ph.D Scholars/JRF) working on following topics:

  • An Epigenetic and transcriptomic study on lncRNA role in oral and cervical cancer Inhibition (Mr. Agnik Haldar, Ph.D student).
  • Identification of inhibitors against oral cancer targets through systems biology approach. (Mr. Keerti Kumar Yadav, Ph.D student)
  • Insilico Inhibitors screening against virulence factors of Porphyromonas gingivalis in oral squamous cell carcinoma (OSCC) Ph.D student)
  • Insilico study on potent inhibitors against iron overload and Cardiac arrhythmia in beta thalassemia (Mr. Piyush Kumar Yadav, Phd student & JRF Under ICMR funded Project)
 
  • Publications :
  • Singh A.K., Misra K*., (2009) In silico study of interactions of curcumin and it’s naturally occurring analogs with Human papilloma virus 16 E6 protein: designing of a herbal drug for oral and cervical cancer” 1st International Conference in Bioinformatics and Computational Biology (BICoB 2009) held in holiday Inn Downtown- Superdome, New Orleans, Louisiana, USA.
  • Singh A.K.a, Misra Kb., Rath S.K.b (2011) Epitopes identification in Indian Human papilloma virus 16 E6 by Bioinformatics approach”. J. Virol. Methods. 177(1):26-30. Elsevier. (Impact factor: 1.786).
  • Singh A.K., Misra K*., (2012) In silico approach for designing potent inhibitors against polymerase PB2 (Influenza A virus: H1N1)”, Proc. Natl. Acad. Sci., India, Sect. B Biol. Sci., 82(3):365–373. Springer. (Impact factor 0.396)
  • Singh A.K., Misra K*.,(2013) “Human papilloma virus 16 E6 protein as a target for curcuminoids, curcumin conjugates and congeners for chemoprevention of oral and cervical cancers”, Interdisciplinary Sciences: Computational Life Sciences. 5(2)112-118. Springer. (Impact factor:1.512).
  • Singh A.K.a Misra K.b., (2018) “2D-QSAR (Quantitative Structure Activity Relationship) Study of Probable Inhibitors for Oral and Cervical Cancers, Generation of Model for Pharmacophore Prediction”. Research & Reviews: A Journal of Drug Design & Discovery. 5(1)1-13. STM Journals.
  • Kamboj Ma., Jain Kb., Singh D.Pc., Singh A.K.d Chaturvedi De.,* (2020) Molecular modeling, in-silico docking and antibacterial studies of novel template wangled macrocyclic complexes involving isatin moiety. Journal of Molecular Structure, (1207)127602. Science Direct. (Impact Factor 2.463).
  • Rani, S., Singh, A.K., Paswan R.R. Kumar K.D., (2020). Preparation, Characterization and Antibacterial Evaluation of Soy Protein Isolate Biopolymeric Films Loaded with Nalidixic Acid. J Polym Environ. Springer (Impact Factor 2.572).
  • Tiwari S.K., Singh A.K., Singh A (2020). In-silico primer designing and PCR for detection of novel coronavirus-19, Journal of Infection and Public Health, (2020) 13(12), 1885-1886. Elsevier. (Impact factor : 2.447)
  • Singh S., Singh A.K. (2020) Mutated USP9X-Associated TRIM33 Inhibition in the Metastasis of Gingivobuccal Oral Squamous Cell Carcinoma Eur. Jour. of Med. And Oncolgy. 4(4): 309-318. Kare Publishing.
  • Haldar, A., Singh, A.K. The association of long non-coding RNA in the prognosis of oral squamous cell carcinoma. Genes Genom (2022). https://doi.org/10.1007/s13258-021-01194-w.
  • Singh A.Ka. Bhargava Aa., Gaur Rb., (2012) Role of Bioinformatics in Microbial study “by in book titled “Microbial Application. (Eds. Gaur R., Malhotra S. and Pandey R.R.) I.K. International Publication, New Delhi. ISBN: 9789381141014
  • Bhargava Aa., Singh A.Ka., Gupta V.Kb. and Gaur R.*, (2012) “Microbes for Heavy Metal Remediation”, in book titled Biotechnology of Microbial Enzymes (Eds. Gaur R., Malhotra S. and Pandey R.R.) I.K. International Publication, New Delhi. ISBN: 9789381141014
  • Singh A.K.,Gupta V.K.,.(2012) “Biological Databases for Microbial Pathways and Enzymes for pathogenesis” in Book tilted Biotechnology of Microbial Enzymes (Eds. Vijai Kumar Gupta and Manimaran Ayyachamy (National University of Ireland, Galway, Ireland), Nova. International Publ, New Delhi. ISBN: 978-1-62100-197-3.
  • Singh A.K., Bhargava A., Kaur G., Sharma A., Misra K. (2012)Bioinformatics tools and resources for cancer diagnosis and drug development. In book titled “Horizons in cancer research” 2012,vol 51 Publishers Nova International USA.
  • Singh A.K., Misra K. “Next Generation Sequencing developments in cancer research by Bioinformatics approaches in book Horizons in cancer research”, Publishers Nova International USA. 2015, ISBN: 978-1-63482-627-3.
  • Singh A.K. (2017)Advances in Computer Aided drug designing in book “Biotechnology Recent trends and emerging dimension”, Ed. Atul Bhargava and S. Srivastava Publisher Taylor and Francis , 2017CRC press. ISBN: 9781138561083.
  • Halder A.a, Yadav K.b , Katara P. C, Singh A.K. * 2020 “Bioinformatics resources for the prediction of cancer prognosis and its recurrence, in book “Recent Trends in computational Omics Concept and Methodology, Ed. Pramod Katara, 2020. Nova Science Publisher, USA.
  • Agnik Haldar A., Singh A.K., (2021) Next-Generation Sequence Analysis for Clinical Applications in Book Titled “Translational Bioinformatics Applications in Healthcare” Ed. Khalid Raza, Nilanjan Dey, pp 23-40, CRC Press. ISBN 9780367705701.
  • Projects :
Sr. No. Title of Project Funding Agency Amount Duration Current Status 1. Evaluation of Human Papilloma Virus in Breast Cancer and its Clinico- pathological Significance (As Co-PI) RMLIMS, Lucknow. 2,00,000 /- 2 Years Completed 2. Networking programme for enrichment and update of plant chromosome database for spermatophytes and Archegoniate. (As Co-PI) DBT, New Delhi 1,93,29 ,000 /- 3 Years Completed 3. Insilico study on potent inhibitors against iron overload and Cardiac arrhythmia in beta thalassemia(As PI) ICMR, New Delhi 33,67,000/- 3 Years Completed
MEMBERSHIP
  • Member of Bioinformatics Society of India.
  • Life Member of UPASTA (Uttar Pradesh Association for science and Technology Advancement)
  • Life Member of IACSIT [International Association of Computer Science and Information Technology], Singapore, December 2012.
  • Member of International association of Engineers, Hong Kong, Since October 2014.
  • Life Member of World Academy of Science, Engineering and Technology
  • Life Membership of Bioinformatics and Drug Discovery Society (BIDDS)
(Membership number - BIDDS17-290)